PI: Susana Minguet, Wolfgang Schamel (link to Minguet CV, link to Schamel CV)
Institution: University of Freiburg, Faculty of Biology, BIOSS Centre for Biological Signalling Studies
Synopsis of research lines:
Our group is based at the University of Freiburg (Germany), the capital of the black forest. We are located at BIOSS centre for Biological signalling studies, which houses experts ranging from immunology, cancer biology and synthetic biology to biochemistry or membrane nanobiology, providing thus a very diverse and multidisciplinary environment.
We aim to understand how T cells are activated by infected and tumor cells. Our main focus are the proteins, lipids and protein complexes that govern the very early steps of T cell activation, such as the T cell antigen receptor (TCR) and its associated signalling proteins. We are interested in the molecular mechanisms of early TCR activation and in applying this knowledge for treatments of human diseases. To this end, we employ biochemistry, synthetic biology, systems biology, mice models and primary cells from healthy human donors or patients.